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Vaccinating with autoimmune or immune-suppressed conditions

People on immunosuppressive medication or with autoimmune conditions often need <em>more</em> vaccinations, not fewer, but the timing and choice of vaccine matters.

8 April 2026 5 min read·Immunisation Hub clinical team
Healthcare consultation reviewing medications
Photo by Hush Naidoo Jade Photography on Unsplash

Photo by Hush Naidoo Jade Photography on Unsplash.

People living with autoimmune conditions, lupus, rheumatoid arthritis, inflammatory bowel disease, MS, psoriasis, often take medications that dampen immune function. That’s the point of those medications, and it has two consequences for vaccination: certain vaccines work less well, and live vaccines are usually avoided.

What’s usually more recommended

  • Annual influenza vaccination.
  • Pneumococcal vaccination, often funded under the NIP for people with specified immunocompromise.
  • COVID-19 boosters per ATAGI advice.
  • Shingles vaccination, the recombinant non-live formulation is often preferred and may be NIP-funded.

What’s usually avoided

Live attenuated vaccines, MMR, varicella, yellow fever, BCG, are usually contraindicated while on significant immunosuppression. Where a live vaccine is needed (yellow fever for travel, for example), specialist input is required and timing around medication changes matters.

Coordinate with your specialist

Many biologics and DMARDs have specific timing windows. Your rheumatologist, gastroenterologist or oncologist will often have a preferred sequence, vaccinate before starting therapy where possible, or in “wash-out” periods. Bring your medication list and specialist correspondence to the consult.

For household contacts

Live vaccines you can’t safely have, like MMR, are still important for the people who live with you. Their vaccination protects you.

General information only. This article is educational and is not a substitute for personal medical advice. Your immuniser will confirm eligibility and contraindications on the day.

TGA advertising compliance. Vaccines are referred to by disease or category in line with the Therapeutic Goods Advertising Code. Specific brands and registered indications are discussed at the consultation.

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